I kind of alluded to this in another thread (the one asking about the big 3s magic number). They cant sellout against Wade and LeBron to such an extent where the 10 points we prevent LeBron and Wade from getting turn into 25 points from other people.
But I think the player that we have to make things tough on is Wade. I think if we could have Wade waste his defense guarding Bogans/Brewer most of the game and turn him into a volume scorer, we have a decent chance. I think turning either James or Wade into volume scorers helps feed one of our strengths which is rebounding. But I think James is more likely to defer so I think Wade is the better option, especially since we dont rely on Bogans or Brewer for that much offense anyway. Also, if we focus on clamping down on James, who knows how much Dengs offense will suffer?