I see three factors really
1. The extra 7+ hours are not a huge deal, but we are talking about a much later night. By the time those guys got back to the locker room, finished with all the interviews and actually got into "recovery mode", I can imagine it was more than just the 7 hours later that they played a game.
2. On the road, nothing more to really say about that.
3. Possible trap/let down game. The win against the Lions made the game last night even more important, so we have this emotional high that everyone is coming off, they might just crash.
My hope is that Nagy and the staff has a plan in place that lets them have a "little" more time to rest, but gets them ready to kick it back into gear on Thursday morning.